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Combined transcriptome and metabolome analyses of metformin effects reveal novel links between metabolic networks in steroidogenic systems

Metformin is an antidiabetic drug, which inhibits mitochondrial respiratory-chain-complex I and thereby seems to affect the cellular metabolism in many ways. It is also used for the treatment of the polycystic ovary syndrome (PCOS), the most common endocrine disorder in women. In addition, metformin...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Udhane, Sameer S., Legeza, Balazs, Marti, Nesa, Hertig, Damian, Diserens, Gaëlle, Nuoffer, Jean-Marc, Vermathen, Peter, Flück, Christa E.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5561186/
https://ncbi.nlm.nih.gov/pubmed/28819133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09189-y
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