Cytochrome P450/ABC transporter inhibition simultaneously enhances ivermectin pharmacokinetics in the mammal host and pharmacodynamics in Anopheles gambiae

Mass administration of endectocides, drugs that kill blood-feeding arthropods, has been proposed as a complementary strategy to reduce malaria transmission. Ivermectin is one of the leading candidates given its excellent safety profile. Here we provide proof that the effect of ivermectin can be boos...

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Udgivet i:Sci Rep
Main Authors: Chaccour, Carlos J., Hammann, Felix, Alustiza, Marta, Castejon, Sandra, Tarimo, Brian B., Abizanda, Gloria, Irigoyen Barrio, Ángel, Martí Soler, Helena, Moncada, Rafael, Bilbao, José Ignacio, Aldaz, Azucena, Maia, Marta, Del Pozo, José Luis
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5561046/
https://ncbi.nlm.nih.gov/pubmed/28819225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08906-x
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