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The Top1 paradox: Friend and foe of the eukaryotic genome

Topoisomerases manage the torsional stress associated with the separation of DNA strands during transcription and DNA replication. Eukaryotic Topoisomerase I (Top1) is a Type IB enzyme that nicks and rejoins only one strand of duplex DNA, and it is especially important during transcription. By resol...

詳細記述

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書誌詳細
出版年:DNA Repair (Amst)
主要な著者: Kim, Nayun, Jinks-Robertson, Sue
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5560766/
https://ncbi.nlm.nih.gov/pubmed/28641942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2017.06.005
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