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TPL-2 restricts Ccl24-dependent immunity to Heligmosomoides polygyrus
TPL-2 (COT, MAP3K8) kinase activates the MEK1/2-ERK1/2 MAPK signaling pathway in innate immune responses following TLR, TNFR1 and IL-1R stimulation. TPL-2 contributes to type-1/Th17-mediated autoimmunity and control of intracellular pathogens. We recently demonstrated TPL-2 reduces severe airway all...
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| Publicado no: | PLoS Pathog |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5560741/ https://ncbi.nlm.nih.gov/pubmed/28759611 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006536 |
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