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Cell surface dynamics and cellular distribution of endogenous FcRn

A major role for FcRn is the salvage of pinocytosed IgG and albumin from a degradative fate in lysosomes. FcRn achieves this by binding IgG in a pH-dependent manner in acidic endosomes and recycling it to the plasma membrane to be released at neutral pH. This is important in maintaining high serum I...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: D’Hooghe, Lena, Chalmers, Andrew D., Heywood, Sam, Whitley, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5560688/
https://ncbi.nlm.nih.gov/pubmed/28817705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182695
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