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Human SLE bone marrow mesenchymal stem cells (BMSCs) have a senescence-associated secretory phenotype (SASP) mediated by a MAVS-IFNβ feedback loop
OBJECTIVE: BMSCs create a special microenvironment for hematopoiesis and immunity and also display robust immunomodulatory properties which are impaired in SLE. This study was undertaken to define the mechanisms of defects in human SLE BMSCs. METHODS: Patients fulfilling SLE classification criteria...
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| Publicado no: | Arthritis Rheumatol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5560120/ https://ncbi.nlm.nih.gov/pubmed/28471483 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.40142 |
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