Transgenic Mice Over-Expressing RBP4 Have RBP4-Dependent and Light-Independent Retinal Degeneration

PURPOSE: Transgenic mice overexpressing serum retinol-binding protein (RBP4-Tg) develop progressive retinal degeneration, characterized by microglia activation, yet the precise mechanisms underlying retinal degeneration are unclear. Previous studies showed RBP4-Tg mice have normal ocular retinoid le...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Du, Mei, Phelps, Eric, Balangue, Michael J., Dockins, Aaron, Moiseyev, Gennadiy, Shin, Younghwa, Kane, Shelley, Otalora, Laura, Ma, Jian-Xing, Farjo, Rafal, Farjo, Krysten M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2017
Assuntos:
Retina
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5560100/
https://ncbi.nlm.nih.gov/pubmed/28813718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.17-22107
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