Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients

PURPOSE: Several small studies have indicated that the ATM rs1801516 SNP is associated with risk of normal tissue toxicity after radiotherapy. However, the findings have not been consistent. In order to test this SNP in a well-powered study, an individual patient data meta-analysis was carried out b...

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Udgivet i:Radiother Oncol
Main Authors: Andreassen, Christian Nicolaj, Rosenstein, Barry S., Kerns, Sarah L., Ostrer, Harry, De Ruysscher, Dirk, Cesaretti, Jamie A., Barnett, Gillian C., Dunning, Alison M., Dorling, Leila, West, Catharine M.L., Burnet, Neil G., Elliott, Rebecca, Coles, Charlotte, Hall, Emma, Fachal, Laura, Vega, Ana, Gómez-Caamaño, Antonio, Talbot, Christopher J., Symonds, R. Paul, De Ruyck, Kim, Thierens, Hubert, Ost, Piet, Chang-Claude, Jenny, Seibold, Petra, Popanda, Odilia, Overgaard, Marie, Dearnaley, David, Sydes, Matthew R., Azria, David, Koch, Christine Anne, Parliament, Matthew, Blackshaw, Michael, Sia, Michael, Fuentes-Raspall, Maria J., Cajal, Teresa Ramon y, Barnadas, Agustin, Vesprini, Danny, Gutiérrez-Enríquez, Sara, Mollà, Meritxell, Díez, Orland, Yarnold, John R., Overgaard, Jens, Bentzen, Søren M., Alsner, Jan
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559879/
https://ncbi.nlm.nih.gov/pubmed/27443449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.radonc.2016.06.017
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