Targeted insertion of an anti-CD2 monoclonal antibody transgene into the GGTA1 locus in pigs using FokI-dCas9

Xenotransplantation from pigs has been advocated as a solution to the perennial shortage of donated human organs and tissues. CRISPR/Cas9 has facilitated the silencing of genes in donor pigs that contribute to xenograft rejection. However, the generation of modified pigs using second-generation nucl...

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Vydáno v:Sci Rep
Hlavní autoři: Nottle, Mark B., Salvaris, Evelyn J., Fisicaro, Nella, McIlfatrick, Stephen, Vassiliev, Ivan, Hawthorne, Wayne J., O’Connell, Philip J., Brady, Jamie L., Lew, Andrew M., Cowan, Peter J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559588/
https://ncbi.nlm.nih.gov/pubmed/28814758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09030-6
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