Social isolation suppresses actin dynamics and synaptic plasticity through ADF/cofilin inactivation in the developing rat barrel cortex

Exposure to a stressful environment early in life can cause psychiatric disorders by disrupting circuit formation. Actin plays central roles in regulating neuronal structure and protein trafficking. We have recently reported that neonatal isolation inactivated ADF/cofilin, the actin depolymerizing f...

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Udgivet i:Sci Rep
Main Authors: Tada, Hirobumi, Miyazaki, Tomoyuki, Takemoto, Kiwamu, Jitsuki, Susumu, Nakajima, Waki, Koide, Mayu, Yamamoto, Naoko, Taguchi, Akiko, Kawai, Honami, Komiya, Kasane, Suyama, Kumiko, Abe, Hiroki, Sano, Akane, Takahashi, Takuya
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559554/
https://ncbi.nlm.nih.gov/pubmed/28814784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08849-3
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