Analytic, Pre-analytic and Clinical Validation of p53 Immunohistochemistry for Detection of TP53 Missense Mutation in Prostate Cancer

PURPOSE: TP53 missense mutations may help to identify prostate cancer (PCa) with lethal potential. Here, we pre-analytically, analytically and clinically validated a robust immunohistochemistry (IHC) assay to detect subclonal and focal TP53 missense mutations in PCa. EXPERIMENTAL DESIGN: The p53 IHC...

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Detaylı Bibliyografya
Yayımlandı:Clin Cancer Res
Asıl Yazarlar: Guedes, Liana B., Almutairi, Fawaz, Haffner, Michael C., Rajoria, Gaurav, Liu, Zach, Klimek, Szczepan, Zoino, Roberto, Yousefi, Kasra, Sharma, Rajni, De Marzo, Angelo M., Netto, George J., Isaacs, William B., Ross, Ashley E., Schaeffer, Edward M., Lotan, Tamara L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559307/
https://ncbi.nlm.nih.gov/pubmed/28446506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-0257
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