Analytic, Pre-analytic and Clinical Validation of p53 Immunohistochemistry for Detection of TP53 Missense Mutation in Prostate Cancer

PURPOSE: TP53 missense mutations may help to identify prostate cancer (PCa) with lethal potential. Here, we pre-analytically, analytically and clinically validated a robust immunohistochemistry (IHC) assay to detect subclonal and focal TP53 missense mutations in PCa. EXPERIMENTAL DESIGN: The p53 IHC...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Guedes, Liana B., Almutairi, Fawaz, Haffner, Michael C., Rajoria, Gaurav, Liu, Zach, Klimek, Szczepan, Zoino, Roberto, Yousefi, Kasra, Sharma, Rajni, De Marzo, Angelo M., Netto, George J., Isaacs, William B., Ross, Ashley E., Schaeffer, Edward M., Lotan, Tamara L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559307/
https://ncbi.nlm.nih.gov/pubmed/28446506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-0257
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