A genome-wide CRISPR screen identifies genes critical for resistance to FLT3 inhibitor AC220

Acute myeloid leukemia (AML) is a malignant hematopoietic disease and the most common type of acute leukemia in adults. The mechanisms underlying drug resistance in AML are poorly understood. Activating mutations in FMS-like tyrosine kinase 3 (FLT3) are the most common molecular abnormality in AML....

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Udgivet i:Cancer Res
Main Authors: Hou, Panpan, Wu, Chao, Wang, Yuchen, Qi, Rui, Bhavanasi, Dheeraj, Zuo, Zhixiang, Santos, Cedric Dos, Chen, Shuliang, Chen, Yu, Zheng, Hong, Wang, Hong, Perl, Alexander, Guo, Deyin, Huang, Jian
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559306/
https://ncbi.nlm.nih.gov/pubmed/28625976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-1627
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