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Bortezomib decreases the magnitude of a primary humoral immune response to transfused RBCs in a murine model

BACKGROUND: Few therapeutic options currently exist to prevent or to mitigate transfusion associated RBC alloimmunization. We hypothesized that bortezomib, a proteasome inhibitor currently being utilized for HLA alloantibody and ADAMTS13 autoantibody reduction, may be beneficial in a transfusion set...

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Publicat a:Transfusion
Autors principals: Natarajan, Prabitha, Liu, Jingchun, Santhanakrishnan, Manjula, Gibb, David R., Slater, Lewis M., Hendrickson, Jeanne E.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559200/
https://ncbi.nlm.nih.gov/pubmed/27734515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/trf.13864
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