Plasma metabolomics reveals membrane lipids, aspartate/asparagine and nucleotide metabolism pathway differences associated with chloroquine resistance in Plasmodium vivax malaria

BACKGROUND: Chloroquine (CQ) is the main anti-schizontocidal drug used in the treatment of uncomplicated malaria caused by Plasmodium vivax. Chloroquine resistant P. vivax (PvCR) malaria in the Western Pacific region, Asia and in the Americas indicates a need for biomarkers of resistance to improve...

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Veröffentlicht in:PLoS One
Hauptverfasser: Uppal, Karan, Salinas, Jorge L., Monteiro, Wuelton M., Val, Fernando, Cordy, Regina J., Liu, Ken, Melo, Gisely C., Siqueira, Andre M., Magalhaes, Belisa, Galinski, Mary R., Lacerda, Marcus V. G., Jones, Dean P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559093/
https://ncbi.nlm.nih.gov/pubmed/28813452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182819
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