Plasma metabolomics reveals membrane lipids, aspartate/asparagine and nucleotide metabolism pathway differences associated with chloroquine resistance in Plasmodium vivax malaria

BACKGROUND: Chloroquine (CQ) is the main anti-schizontocidal drug used in the treatment of uncomplicated malaria caused by Plasmodium vivax. Chloroquine resistant P. vivax (PvCR) malaria in the Western Pacific region, Asia and in the Americas indicates a need for biomarkers of resistance to improve...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Uppal, Karan, Salinas, Jorge L., Monteiro, Wuelton M., Val, Fernando, Cordy, Regina J., Liu, Ken, Melo, Gisely C., Siqueira, Andre M., Magalhaes, Belisa, Galinski, Mary R., Lacerda, Marcus V. G., Jones, Dean P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559093/
https://ncbi.nlm.nih.gov/pubmed/28813452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182819
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