Two functionally distinct E2/E3 pairs coordinate sequential ubiquitination of a common substrate in Caenorhabditis elegans development

Ubiquitination, the crucial posttranslational modification that regulates the eukaryotic proteome, is carried out by a trio of enzymes, known as E1 [ubiquitin (Ub)-activating enzyme], E2 (Ub-conjugating enzyme), and E3 (Ub ligase). Although most E2s can work with any of the three mechanistically dis...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Dove, Katja K., Kemp, Hilary A., Di Bona, Kristin R., Reiter, Katherine H., Milburn, Luke J., Camacho, David, Fay, David S., Miller, Dana L., Klevit, Rachel E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559030/
https://ncbi.nlm.nih.gov/pubmed/28739890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705060114
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