Mitogenic stimulation accelerates influenza-induced mortality by increasing susceptibility of alveolar type II cells to infection

Development of pneumonia is the most lethal consequence of influenza, increasing mortality more than 50-fold compared with uncomplicated infection. The spread of viral infection from conducting airways to the alveolar epithelium is therefore a pivotal event in influenza pathogenesis. We found that m...

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Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Nikolaidis, Nikolaos M., Noel, John G., Pitstick, Lori B., Gardner, Jason C., Uehara, Yasuaki, Wu, Huixing, Saito, Atsushi, Lewnard, Kara E., Liu, Huan, White, Mitchell R., Hartshorn, Kevan L., McCormack, Francis X.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2017
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PNAS Plus
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5558995/
https://ncbi.nlm.nih.gov/pubmed/28739896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1621172114
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