Mitogenic stimulation accelerates influenza-induced mortality by increasing susceptibility of alveolar type II cells to infection

Development of pneumonia is the most lethal consequence of influenza, increasing mortality more than 50-fold compared with uncomplicated infection. The spread of viral infection from conducting airways to the alveolar epithelium is therefore a pivotal event in influenza pathogenesis. We found that m...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Nikolaidis, Nikolaos M., Noel, John G., Pitstick, Lori B., Gardner, Jason C., Uehara, Yasuaki, Wu, Huixing, Saito, Atsushi, Lewnard, Kara E., Liu, Huan, White, Mitchell R., Hartshorn, Kevan L., McCormack, Francis X.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5558995/
https://ncbi.nlm.nih.gov/pubmed/28739896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1621172114
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