Intramolecular Hydrogen Bonding Restricts Gd-Aqua Ligand Dynamics

Aqua ligands can undergo rapid internal rotation about the M-O bond. For magnetic resonance contrast agents, this rotation results in diminished relaxivity. Here we show that an intramolecular hydrogen bond to the aqua ligand can reduce this internal rotation and increase relaxivity. Molecular model...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Angew Chem Int Ed Engl
Autori principali: Boros, Eszter, Srinivas, Raja, Kim, Hee-Kyung, Raitsimring, Arnold M., Astashkin, Andrei V., Poluektov, Oleg G., Niklas, Jens, Horning, Andrew D., Tidor, Bruce, Caravan, Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5558827/
https://ncbi.nlm.nih.gov/pubmed/28398613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201702274
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi