Characterization of the Zika virus two-component NS2B-NS3 protease and structure-assisted identification of allosteric small-molecule antagonists()

The recent re-emergence of Zika virus (ZIKV)(1), a member of the Flaviviridae family, has become a global emergency. Currently, there are no effective methods of preventing or treating ZIKV infection, which causes severe neuroimmunopathology and is particularly harmful to the developing fetuses of i...

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Vydáno v:Antiviral Res
Hlavní autoři: Shiryaev, Sergey A., Farhy, Chen, Pinto, Antonella, Huang, Chun-Teng, Simonetti, Nicole, Ngono, Annie Elong, Dewing, Antimone, Shresta, Sujan, Pinkerton, Anthony B., Cieplak, Piotr, Strongin, Alex Y., Terskikh, Alexey V.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5558795/
https://ncbi.nlm.nih.gov/pubmed/28461069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2017.04.015
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