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A tale of two glutaminases: homologous enzymes with distinct roles in tumorigenesis
Many cancer cells exhibit an altered metabolic phenotype, in which glutamine consumption is upregulated relative to healthy cells. This metabolic reprogramming often depends upon mitochondrial glutaminase activity, which converts glutamine to glutamate, a key precursor for biosynthetic and bioenerge...
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| 發表在: | Future Med Chem |
|---|---|
| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Future Science Ltd
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5558546/ https://ncbi.nlm.nih.gov/pubmed/28111979 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fmc-2016-0190 |
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