Inhibition of connexin hemichannels alleviates non-alcoholic steatohepatitis in mice

While gap junctions mediate intercellular communication and support liver homeostasis, connexin hemichannels are preferentially opened by pathological stimuli, including inflammation and oxidative stress. The latter are essential features of non-alcoholic steatohepatitis. In this study, it was inves...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Willebrords, Joost, Cogliati, Bruno, Pereira, Isabel Veloso Alves, da Silva, Tereza Cristina, Crespo Yanguas, Sara, Maes, Michaël, Govoni, Veronica Mollica, Lima, Andressa, Felisbino, Daniele Aparecida, Decrock, Elke, Nogueira, Marina Sayuri, de Castro, Inar Alves, Leclercq, Isabelle, Leybaert, Luc, Rodrigues, Robim Marcelino, Vinken, Mathieu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5557827/
https://ncbi.nlm.nih.gov/pubmed/28811572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08583-w
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