Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation

Immunoreceptors can transduce either inhibitory or activatory signals depending on ligand avidity and phosphorylation status, which is modulated by the protein kinases Lyn and Fyn. Here we show that Lyn and Fyn control immune receptor signaling status. SHP-1 tyrosine 536 phosphorylation by Lyn activ...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Mkaddem, Sanae Ben, Murua, Amaya, Flament, Héloise, Titeca-Beauport, Dimitri, Bounaix, Carine, Danelli, Luca, Launay, Pierre, Benhamou, Marc, Blank, Ulrich, Daugas, Eric, Charles, Nicolas, Monteiro, Renato C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5557797/
https://ncbi.nlm.nih.gov/pubmed/28811476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00294-0
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