Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation

Immunoreceptors can transduce either inhibitory or activatory signals depending on ligand avidity and phosphorylation status, which is modulated by the protein kinases Lyn and Fyn. Here we show that Lyn and Fyn control immune receptor signaling status. SHP-1 tyrosine 536 phosphorylation by Lyn activ...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: Mkaddem, Sanae Ben, Murua, Amaya, Flament, Héloise, Titeca-Beauport, Dimitri, Bounaix, Carine, Danelli, Luca, Launay, Pierre, Benhamou, Marc, Blank, Ulrich, Daugas, Eric, Charles, Nicolas, Monteiro, Renato C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5557797/
https://ncbi.nlm.nih.gov/pubmed/28811476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00294-0
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