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Atherosusceptible Shear Stress Activates Endoplasmic Reticulum Stress to Promote Endothelial Inflammation

Atherosclerosis impacts arteries where disturbed blood flow renders the endothelium susceptible to inflammation. Cytokine activation of endothelial cells (EC) upregulates VCAM-1 receptors that target monocyte recruitment to atherosusceptible regions. Endoplasmic reticulum (ER) stress elicits EC dysr...

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Publicat a:Sci Rep
Autors principals: Bailey, Keith A., Haj, Fawaz G., Simon, Scott I., Passerini, Anthony G.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5557756/
https://ncbi.nlm.nih.gov/pubmed/28811527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08417-9
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