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Stochastic simulations of the origins and implications of long-tailed distributions in gene expression

Gene expression noise results in protein number distributions ranging from long-tailed to Gaussian. We show how long-tailed distributions arise from a stochastic model of the constituent chemical reactions and suggest that, in conjunction with cooperative switches, they lead to more sensitive select...

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Autors principals: Krishna, Sandeep, Banerjee, Bidisha, Ramakrishnan, T. V., Shivashankar, G. V.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC555697/
https://ncbi.nlm.nih.gov/pubmed/15772163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406415102
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