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Tumor-derived exosomes induce CD8(+) T cell suppressors

BACKGROUND: The suppressive nature of immune cells in the tumor microenvironment plays a major role in regulating anti-tumor immune responses. Our previous work demonstrated that a soluble factor from tumor cells is able to induce a suppressor phenotype (SP) in human CD8(+) T cells typified by loss...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Maybruck, Brian T., Pfannenstiel, Lukas W., Diaz-Montero, Marcela, Gastman, Brian R.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5556362/
https://ncbi.nlm.nih.gov/pubmed/28806909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-017-0269-7
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