A combinatorial approach for the discovery of cytochrome P450 2D6 inhibitors from nature

The human cytochrome P450 2D6 (CYP2D6) enzyme is part of phase-I metabolism and metabolizes at least 20% of all clinically relevant drugs. Therefore, it is an important target for drug-drug interaction (DDI) studies. High-throughput screening (HTS) assays are commonly used tools to examine DDI, but...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Hochleitner, Johannes, Akram, Muhammad, Ueberall, Martina, Davis, Rohan A., Waltenberger, Birgit, Stuppner, Hermann, Sturm, Sonja, Ueberall, Florian, Gostner, Johanna M., Schuster, Daniela
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5556109/
https://ncbi.nlm.nih.gov/pubmed/28808272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08404-0
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