Genetic evidence of a precisely tuned dysregulation in the hypoxia signaling pathway during oncogenesis

The classic model of tumor suppression implies that malignant transformation requires full 'two-hit' inactivation of a tumor suppressor gene. However, more recent work in mice has led to the proposal of a "continuum" model that involves more fluid concepts such as gene dosage-sen...

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Published in:Cancer Res
Main Authors: Couvé, Sophie, Ladroue, Charline, Laine, Elodie, Mahtouk, Karène, Guégan, Justine, Gad, Sophie, Le Jeune, Hélène, Le Gentil, Marion, Nuel, Gregory, Kim, William Y., Lecomte, Bernard, Pagès, Jean-Christophe, Collin, Christine, Lasne, Françoise, Benusiglio, Patrick R., Bressac-de Paillerets, Brigitte, Feunteun, Jean, Lazar, Vladimir, Gimenez-Roqueplo, Anne-Paule, Mazure, Nathalie M., Dessen, Philippe, Tchertanov, Luba, Mole, David, Kaelin, William, Ratcliffe, Peter, Richard, Stéphane, Gardie, Betty
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5555745/
https://ncbi.nlm.nih.gov/pubmed/25371412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-1161
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