Partial IGF-1 deficiency is sufficient to reduce heart contractibility, angiotensin II sensibility, and alter gene expression of structural and functional cardiac proteins

Circulating levels of IGF-1 may decrease under several circumstances like ageing, metabolic syndrome, and advanced cirrhosis. This reduction is associated with insulin resistance, dyslipidemia, progression to type 2 diabetes, and increased risk for cardiovascular diseases. However, underlying mechan...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: González-Guerra, José Luis, Castilla-Cortazar, Inma, Aguirre, Gabriel A., Muñoz, Úrsula, Martín-Estal, Irene, Ávila-Gallego, Elena, Granado, Miriam, Puche, Juan E., García-Villalón, Ángel Luis
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5555709/
https://ncbi.nlm.nih.gov/pubmed/28806738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0181760
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