Experimental approach to IGF-1 therapy in CCl(4)-induced acute liver damage in healthy controls and mice with partial IGF-1 deficiency

BACKGROUND: Cell necrosis, oxidative damage, and fibrogenesis are involved in cirrhosis development, a condition in which insulin-like growth factor 1 (IGF-1) levels are diminished. This study evaluates whether the exogenous administration of low doses of IGF-1 can induce hepatoprotection in acute c...

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Publicat a:J Transl Med
Autors principals: Morales-Garza, Luis A., Puche, Juan E., Aguirre, Gabriel A., Muñoz, Úrsula, García-Magariño, Mariano, De la Garza, Rocío G., Castilla-Cortazar, Inma
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2017
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418730/
https://ncbi.nlm.nih.gov/pubmed/28472963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-017-1198-4
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