Alpha-tocopherol attenuates the anti-tumor activity of crizotinib against cells transformed by NPM-ALK

Anaplastic large cell lymphomas (ALCL) are mainly characterized by harboring the fusion protein nucleophosmin-anaplastic lymphoma kinase (NPM-ALK). The ALK inhibitor, crizotinib specifically induced apoptosis in Ba/F3 cells expressing NPM-ALK by inhibiting the activation of NPM-ALK and its downstrea...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Uchihara, Yuki, Ueda, Fumihito, Tago, Kenji, Nakazawa, Yosuke, Ohe, Tomoyuki, Mashino, Tadahiko, Yokota, Shigenobu, Kasahara, Tadashi, Tamura, Hiroomi, Funakoshi-Tago, Megumi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5555621/
https://ncbi.nlm.nih.gov/pubmed/28806414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0183003
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