ERK2 and JNK1 contribute to TNF-α-induced IL-8 expression in synovial fibroblasts

Tumor necrosis factor α (TNF-α) induces the expression and secretion of interleukin 8 (IL-8), which contributes to synovitis in rheumatoid arthritis (RA). To elucidate the mechanism of the onset of RA, we used synovial fibroblasts without autoimmune inflammatory diseases and investigated MAPK signal...

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Udgivet i:PLoS One
Main Authors: Namba, Shinichi, Nakano, Rei, Kitanaka, Taku, Kitanaka, Nanako, Nakayama, Tomohiro, Sugiya, Hiroshi
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5555573/
https://ncbi.nlm.nih.gov/pubmed/28806729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182923
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