Fifteen new risk loci for coronary artery disease highlight arterial wall-specific mechanisms

Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide1,2. Although 58 genomic regions have been associated with CAD to date3–9, most of the heritability is unexplained9, indicating additional susceptibility loci await identification. An efficient discovery strategy ma...

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Publicado no:Nat Genet
Main Authors: Howson, Joanna M.M., Zhao, Wei, Barnes, Daniel R., Ho, Weang-Kee, Young, Robin, Paul, Dirk S., Waite, Lindsay L., Freitag, Daniel F., Fauman, Eric B., Salfati, Elias L., Sun, Benjamin B., Eicher, John D., Johnson, Andrew D., Sheu, Wayne H.H., Nielsen, Sune F., Lin, Wei-Yu, Surendran, Praveen, Malarstig, Anders, Wilk, Jemma B., Tybjærg-Hansen, Anne, Rasmussen, Katrine L., Kamstrup, Pia R., Deloukas, Panos, Erdmann, Jeanette, Kathiresan, Sekar, Samani, Nilesh J., Schunkert, Heribert, Watkins, Hugh, Do, Ron, Rader, Daniel J., Johnson, Julie A., Hazen, Stanley L., Quyyumi, Arshed, Spertus, John A., Pepine, Carl J., Franceschini, Nora, Justice, Anne, Reiner, Alex P., Buyske, Steven, Hindorff, Lucia A., Carty, Cara L., North, Kari E., Kooperberg, Charles, Boerwinkle, Eric, Young, Kristin, Graff, Mariaelisa, Peters, Ulrike, Absher, Devin, Hsiung, Chao A., Lee, Wen-Jane, Taylor, Kent D., Chen, Ying-Hsiang, Lee, I-Te, Guo, Xiuqing, Chung, Ren-Hua, Hung, Yi-Jen, Rotter, Jerome I., Juang, Jyh-Ming J., Quertermous, Thomas, Wang, Tzung-Dau, Rasheed, Asif, Frossard, Philippe, Alam, Dewan S., Majumder, Abdulla al Shafi, Di Angelantonio, Emanuele, Chowdhury, Rajiv, Chen, Yii-Der Ida., Nordestgaard, Børge G., Assimes, Themistocles L., Danesh, John, Butterworth, Adam S., Saleheen, Danish
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5555387/
https://ncbi.nlm.nih.gov/pubmed/28530674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3874
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