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Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states
Thymidylate synthase (TS) is the sole enzyme responsible for de novo biosynthesis of thymidylate (TMP) and is essential for cell proliferation and survival. Inhibition of human TS (hTS) has been extensively investigated for cancer chemotherapy, but several aspects of its activity and regulation are...
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| Udgivet i: | J Biol Chem |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5555203/ https://ncbi.nlm.nih.gov/pubmed/28634233 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.787267 |
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