Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel β4 subunit explain its role in cell–cell adhesion

Voltage-gated sodium channels (VGSCs) are transmembrane proteins required for the generation of action potentials in excitable cells and essential for propagating electrical impulses along nerve cells. VGSCs are complexes of a pore-forming α subunit and auxiliary β subunits, designated as β1/β1B–β4...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Shimizu, Hideaki, Tosaki, Asako, Ohsawa, Noboru, Ishizuka-Katsura, Yoshiko, Shoji, Shisako, Miyazaki, Haruko, Oyama, Fumitaka, Terada, Takaho, Shirouzu, Mikako, Sekine, Shun-ichi, Nukina, Nobuyuki, Yokoyama, Shigeyuki
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2017
Sujets:
Protein Structure and Folding
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5555201/
https://ncbi.nlm.nih.gov/pubmed/28655765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.786509
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