Intramembrane attenuation of the TLR4-TLR6 dimer impairs receptor assembly and reduces microglia-mediated neurodegeneration

Recently, a single study revealed a new complex composed of Toll-like receptor 4 (TLR4), TLR6, and CD36 induced by fibrillary Aβ peptides, the hallmark of Alzheimer's disease. Unlike TLRs located on the plasma membrane that dimerize on the membrane after ligand binding to their extracellular do...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Shmuel-Galia, Liraz, Klug, Yoel, Porat, Ziv, Charni, Meital, Zarmi, Batya, Shai, Yechiel
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5555200/
https://ncbi.nlm.nih.gov/pubmed/28655763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.784983
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