Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models

[Image: see text] Histone lysine demethylases (KDMs) play a vital role in the regulation of chromatin-related processes. Herein, we describe our discovery of a series of potent KDM4 inhibitors that are both cell permeable and antiproliferative in cancer models. The modulation of histone H3K9me3 and...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Chen, Young K., Bonaldi, Tiziana, Cuomo, Alessandro, Del Rosario, Joselyn R., Hosfield, David J., Kanouni, Toufike, Kao, Shih-chu, Lai, Chon, Lobo, Neethan A., Matuszkiewicz, Jennifer, McGeehan, Andrew, O’Connell, Shawn M., Shi, Lihong, Stafford, Jeffrey A., Stansfield, Ryan K., Veal, James M., Weiss, Michael S., Yuen, Natalie Y., Wallace, Michael B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5554903/
https://ncbi.nlm.nih.gov/pubmed/28835804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00220
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