Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models

[Image: see text] Histone lysine demethylases (KDMs) play a vital role in the regulation of chromatin-related processes. Herein, we describe our discovery of a series of potent KDM4 inhibitors that are both cell permeable and antiproliferative in cancer models. The modulation of histone H3K9me3 and...

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Detaylı Bibliyografya
Yayımlandı:ACS Med Chem Lett
Asıl Yazarlar: Chen, Young K., Bonaldi, Tiziana, Cuomo, Alessandro, Del Rosario, Joselyn R., Hosfield, David J., Kanouni, Toufike, Kao, Shih-chu, Lai, Chon, Lobo, Neethan A., Matuszkiewicz, Jennifer, McGeehan, Andrew, O’Connell, Shawn M., Shi, Lihong, Stafford, Jeffrey A., Stansfield, Ryan K., Veal, James M., Weiss, Michael S., Yuen, Natalie Y., Wallace, Michael B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2017
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5554903/
https://ncbi.nlm.nih.gov/pubmed/28835804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00220
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