Synthesis and Activity of a New Series of Antileishmanial Agents

[Image: see text] We have determined that tetrahydroindazoles such as 1 show potent activity against Leishmania donovani, the causative agent of leishmaniasis. While the Hsp90 activity and anticancer properties of 1 have previously been explored, we present here our efforts to optimize their activit...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Kanwar, Ankush, Eduful, Benjamin J., Barbeto, Linda, Carletti Bonomo, Piero, Lemus, Andrea, Vesely, Brian A., Mutka, Tina S., Azhari, Ala, Kyle, Dennis E., Leahy, James W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5554902/
https://ncbi.nlm.nih.gov/pubmed/28835791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00039
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