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The polyglutamine neurodegenerative protein ataxin 3 regulates aggresome formation
The polyglutamine-containing neurodegenerative protein ataxin 3 (AT3) has deubiquitylating activity and binds ubiquitin chains with a preference for chains of four or more ubiquitins. Here we characterize the deubiquitylating activity of AT3 in vitro and show it trims/edits K48-linked ubiquitin chai...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC555481/ https://ncbi.nlm.nih.gov/pubmed/15767577 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407252102 |
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