Oligonucleotide-addressed covalent 3’-terminal derivatization of small RNA strands for enrichment and visualization

The HEN1 RNA 2’-O-methyltransferase plays important roles in biogenesis of small non-coding RNAs in plants and proved a valuable tool for selective transfer of functional groups from cofactor analogues onto miRNA and siRNA duplexes in vitro. Herein, we demonstrate versatile HEN1-mediated methylation...

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Publicado en:Angew Chem Int Ed Engl
Autores principales: Osipenko, Aleksandr, Plotnikova, Alexandra, Nainytė, Milda, Masevičius, Viktoras, Klimašauskas, Saulius, Vilkaitis, Giedrius
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5554592/
https://ncbi.nlm.nih.gov/pubmed/28471013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201701448
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