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Interspecies Variation of In Vitro Stability and Metabolic Diversity of YZG-331, a Promising Sedative-Hypnotic Compound

YZG-331, a synthetic adenosine derivative, express the sedative and hypnotic effects via binding to the adenosine receptor. The current study was taken to investigate the metabolic pathway of YZG-331 as well as species-specific differences in vitro. YZG-331 was reduced by 14, 11, 6, 46, and 11% with...

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Опубликовано в: :Front Pharmacol
Главные авторы: Liu, Zhihao, Yang, Yakun, Sheng, Li, Li, Yan
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5554529/
https://ncbi.nlm.nih.gov/pubmed/28848441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00527
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