TNFα induced up-regulation of Na(+),K(+),2Cl(−) cotransporter NKCC1 in hepatic ammonia clearance and cerebral ammonia toxicity

The devastating consequences of hepatic failure include hepatic encephalopathy, a severe, life threatening impairment of neuronal function. Hepatic encephalopathy is caused by impaired hepatic clearance of NH(4) (+). Cellular NH(4) (+) uptake is accomplished mainly by the Na(+),K(+),2Cl(−) cotranspo...

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Publicado no:Sci Rep
Main Authors: Pozdeev, Vitaly I., Lang, Elisabeth, Görg, Boris, Bidmon, Hans J., Shinde, Prashant V., Kircheis, Gerald, Herebian, Diran, Pfeffer, Klaus, Lang, Florian, Häussinger, Dieter, Lang, Karl S., Lang, Philipp A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5554233/
https://ncbi.nlm.nih.gov/pubmed/28801579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07640-8
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