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Temozolomide arrests glioma growth and normalizes intratumoral extracellular pH

Gliomas maintain an acidic extracellular pH (pH(e)), which promotes tumor growth and builds resistance to therapy. Given evidence that acidic pH(e) beyond the tumor core indicates infiltration, we hypothesized that imaging the intratumoral pH(e) in relation to the peritumoral pH(e) can provide a nov...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Rao, Jyotsna U., Coman, Daniel, Walsh, John J., Ali, Meser M., Huang, Yuegao, Hyder, Fahmeed
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5554228/
https://ncbi.nlm.nih.gov/pubmed/28801587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07609-7
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