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Temozolomide arrests glioma growth and normalizes intratumoral extracellular pH
Gliomas maintain an acidic extracellular pH (pH(e)), which promotes tumor growth and builds resistance to therapy. Given evidence that acidic pH(e) beyond the tumor core indicates infiltration, we hypothesized that imaging the intratumoral pH(e) in relation to the peritumoral pH(e) can provide a nov...
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Publicado no: | Sci Rep |
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Main Authors: | , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Nature Publishing Group UK
2017
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5554228/ https://ncbi.nlm.nih.gov/pubmed/28801587 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07609-7 |
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