Regulation of the Human Phosphatase PTPN4 by the inter-domain linker connecting the PDZ and the phosphatase domains

Human protein tyrosine phosphatase non-receptor type 4 (PTPN4) has been shown to prevent cell death. The active form of human PTPN4 consists of two globular domains, a PDZ (PSD-95/Dlg/ZO-1) domain and a phosphatase domain, tethered by a flexible linker. Targeting its PDZ domain abrogates this protec...

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Publicado no:Sci Rep
Main Authors: Caillet-Saguy, Célia, Toto, Angelo, Guerois, Raphael, Maisonneuve, Pierre, di Silvio, Eva, Sawyer, Kristi, Gianni, Stefano, Wolff, Nicolas
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5554198/
https://ncbi.nlm.nih.gov/pubmed/28801650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08193-6
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