Protein O-mannosylation deficiency increases LprG-associated lipoarabinomannan release by Mycobacterium tuberculosis and enhances the TLR2-associated inflammatory response

Protein O-mannosylation is crucial for the biology of Mycobacterium tuberculosis but the key mannosylated protein(s) involved and its(their) underlying function(s) remain unknown. Here, we demonstrated that the M. tuberculosis mutant (Δpmt) deficient for protein O-mannosylation exhibits enhanced rel...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Alonso, Henar, Parra, Julien, Malaga, Wladimir, Payros, Delphine, Liu, Chia-Fang, Berrone, Céline, Robert, Camille, Meunier, Etienne, Burlet-Schiltz, Odile, Rivière, Michel, Guilhot, Christophe
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5554173/
https://ncbi.nlm.nih.gov/pubmed/28801649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08489-7
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