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A structural and mechanistic study of π-clamp-mediated cysteine perfluoroarylation
Natural enzymes use local environments to tune the reactivity of amino acid side chains. In searching for small peptides with similar properties, we discovered a four-residue π-clamp motif (Phe-Cys-Pro-Phe) for regio- and chemoselective arylation of cysteine in ribosomally produced proteins. Here we...
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| Publicat a: | Sci Rep |
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| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5554146/ https://ncbi.nlm.nih.gov/pubmed/28801573 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08402-2 |
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