A structural and mechanistic study of π-clamp-mediated cysteine perfluoroarylation

Natural enzymes use local environments to tune the reactivity of amino acid side chains. In searching for small peptides with similar properties, we discovered a four-residue π-clamp motif (Phe-Cys-Pro-Phe) for regio- and chemoselective arylation of cysteine in ribosomally produced proteins. Here we...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Dai, Peng, Williams, Jonathan K., Zhang, Chi, Welborn, Matthew, Shepherd, James J., Zhu, Tianyu, Van Voorhis, Troy, Hong, Mei, Pentelute, Bradley L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5554146/
https://ncbi.nlm.nih.gov/pubmed/28801573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08402-2
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