Site-Selective Cysteine-Cyclooctyne Conjugation

We report a site-selective cysteine-cyclooctyne conjugation reaction between a seven-residue peptide tag (DBCO-tag, Leu-Cys-Tyr-Pro-Trp-Val-Tyr), at the N or C-terminus of a peptide or protein, and various aza-dibenzocyclooctyne (DBCO) reagents. Compared to a cysteine peptide control, the DBCO-tag i...

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發表在:Angew Chem Int Ed Engl
Main Authors: Zhang, Chi, Dai, Peng, Vinogradov, Alexander A., Gates, Zachary P., Pentelute, Bradley L.
格式: Artigo
語言:Inglês
出版: 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6150453/
https://ncbi.nlm.nih.gov/pubmed/29575377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201800860
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