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Mesenchymal tumorigenesis driven by TSC2 haploinsufficiency requires HMGA2 and is independent of mTOR pathway activation
Tuberous sclerosis (TSC) is a tumor suppressor gene syndrome that is associated with the widespread development of mesenchymal tumor types. Genetically, TSC is said to occur through a classical bi-allelic inactivation of either TSC genes (TSC1, hamartin or TSC2, tuberin), an event that is implicated...
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| Publicado en: | Cancer Res |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5554010/ https://ncbi.nlm.nih.gov/pubmed/26837766 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1287 |
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